The industry-standard magnetic beads deliver consistent results. But they come at a premium price that strains your budget. Cheaper alternatives promise savings, but batch-to-batch variation keeps you guessing whether today's cleanup will match yesterday's. You shouldn't have to choose between quality or cost.

AmpliClean™: Fast and reliable DNA cleanup without the complexity
NimaGen's AmpliClean™ combines proven magnetic bead technology with cost-effective pricing. Designed as a trusted drop-in alternative to AMPure® XP, AmpliClean™ recovers DNA fragments >100 bp with the consistency and reproducibility your workflows demand without the premium price tag.

AmpliClean™ cleanup kit
- Designed for standard cleanup of DNA fragments >100 bp
- High-yield, high-purity DNA for PCR purification, Sanger Sequencing, and NGS
- Cost-effective alternative to AMPure® XP beads
The simple workflow you know, now optimized
AmpliClean™ follows the same trusted three-step process you rely on:
- Bind – Long DNA fragments selectively bind to paramagnetic beads
- Wash – Salts, primers, dimers, nucleotides, and short contaminants are removed with ethanol
- Elute – Ultra-pure DNA is recovered, directly ready for downstream applications
No centrifugation. No vacuum filtration. Just reliable, high-quality DNA in three simple steps.

“NimaGen’s AmpliClean™ combines proven magnetic bead technology with cost-effective pricing.”
Why labs trust AmpliClean™?

Every cleanup delivers the same high recovery and purity. No batch variation, no protocol adjustments, no surprises. Your results stay consistent from the first reaction to the thousandth.

Primers, primer-dimers, salts, dNTPs; AmpliClean™ removes them efficiently and completely. The result: ultra-pure DNA ready for immediate downstream use.

Delivers gold-standard equivalent results at a competitive price point. An economical choice for both routine purification and high-throughput sequencing applications.


Tired of unwanted short fragments?
For DNA fragments between 1-6 kb, explore AmpliClean™ LF, specifically optimized for long-fragment cleanup with superior removal of short contaminants

Why choose AmpliClean™?
- Reliable results: high recovery and purity, every time
- Superior performance for long fragments: proven removal of short background DNA
- Validated by customers: improved sequencing specificity and data quality
- Automation-ready: compatible with Alpaqua® magnet plates and liquid handlers
- Flexibility: suited for both small-scale manual workflows and high-throughput automation
AmpliClean™ adapts to your setup
Whether you run manual single-tube workflows or high-throughput sequencing facilities, AmpliClean™ adapts to your setup. The protocol offers high flexibility for manual operation and integrates seamlessly with liquid handling systems. Fully compatible with Alpaqua® magnet plates (96-well and 384-well formats), making it ideal for labs scaling up their sequencing operations.
Ideal applications
- PCR product purification
- Sanger sequencing cleanup
- NGS library preparation
- Microarray sample preparation
- Any workflow requiring reliable removal of primers, salts and nucleotides
Request your AmpliClean™ test sample
Want to see consistent results in your own workflow? Request a test sample of AmpliClean™ and experience reliable magnetic bead cleanup at a competitive price.