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Product Information

Rapid and Effective Magnetic DyeTerminator Cleanup

Intended use

The D-Pure™ DyeTerminator Cleanup Kit efficiently removes unincorporated dyeterminators and salt-ions from extension products cycle sequenced with BrilliantDye™ and BigDye™ chemistries.


Magnetic cleanup is completed directly on the cycle sequencing plate and can be processed both manually and automated. Purified dye-labeled extension products can be loaded directly on the Genetic Analyzers without the need for resuspension.


D-Pure™ effectively eliminates the presence of dye-blobs, through selective binding and high washing efficiency, allowing for cleaner sequences and more confident signal reading. 


D-Pure™ DyeTerminator Cleanup kits are widely adopted as proven, high-quality reagents for laboratories using 3130, 3500, 3730 Series Genetic Analyzers and SeqStudio™, and are compatible with BigDye™ and BrilliantDye™ Cycle Sequencing (v1.1 and v3.1) Kits. 


D-Pure™ DyeTerminator Cleanup can be used in conjunction with Alpaqua® magnet plates, e.g. the Magnum FLX® and 96S Super Magnet Plates.


The high-quality alternative for magnetic bead-based CleanSEQ Dye-Terminator Removal Kit or resin-based BigDye XTerminator™.


BigDye and and SeqStudio are trademarks of Thermo Fisher Scientific. CleanSEQ is a trademark of Beckman Coulter.

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  • Fast, reliable, proven, reproducible
  • Efficient removal of cycle sequencing reaction contaminants
  • Excellent short and long fragment recovery
  • Straightforward workflow, both manually and automated
  • No liquid transfer: cycle sequencing and clean-up in a single plate
  • No centrifugation or filtration steps
  • Compatible with BigDye XTerminator™ run modules
Also Available

Alpaqua® Magnet Plates

NimaGen offers a broad range of Alpaqua® magnet plates, the leading and most frequently recommended brand for magnetic separation devices.

Alpaqua® magnets are the most widely used magnet plates used in combination with D-Pure™ DyeTerminator Cleanup Kit or CleanSEQ Dye-Terminator Removal Kit for magnetic bead-based cycle sequencing reaction cleanup, and with AmpliClean™ Cleanup Kit or AMPure XP for cleanup of PCR reactions or preparation of sequencing ready NGS libraries.

View Alpaqua® Magnet Plates